Gregory A Grabowski Selected Research

Gaucher Disease (Gaucher's Disease)

1/2021	Gaucher disease: Basic and translational science needs for more complete therapy and management.
1/2021	Substrate Reduction Therapy Reverses Mitochondrial, mTOR, and Autophagy Alterations in a Cell Model of Gaucher Disease.
5/2020	Systemic enzyme delivery by blood-brain barrier-penetrating SapC-DOPS nanovesicles for treatment of neuronopathic Gaucher disease.
10/2019	Intravenous infusion of iPSC-derived neural precursor cells increases acid β-glucosidase function in the brain and lessens the neuronopathic phenotype in a mouse model of Gaucher disease.
1/2019	Combination of acid β-glucosidase mutation and Saposin C deficiency in mice reveals Gba1 mutation dependent and tissue-specific disease phenotype.
2/2018	Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher Disease.
1/2018	An unexpected player in Gaucher disease: The multiple roles of complement in disease development.
12/2017	Tissue Localization of Glycosphingolipid Accumulation in a Gaucher Disease Mouse Brain by LC-ESI-MS/MS and High-Resolution MALDI Imaging Mass Spectrometry.
1/2017	Ten plus one challenges in diseases of the lysosomal system.
1/2017	Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease.

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Gregory A Grabowski Research Topics

Disease

69	Gaucher Disease (Gaucher's Disease) 01/2021 - 01/2003
21	Lysosomal Storage Diseases (Lysosomal Storage Disease) 05/2020 - 01/2003
6	Inflammation (Inflammations) 01/2018 - 02/2014
4	Atherosclerosis 01/2018 - 01/2004
4	Parkinson Disease (Parkinson's Disease) 01/2017 - 06/2011
4	Fabry Disease (Fabry's Disease) 01/2012 - 01/2003
4	Disease Progression 10/2008 - 01/2003
3	Neoplasms (Cancer) 01/2017 - 01/2004
3	Mitochondrial Diseases (Mitochondrial Disease) 12/2015 - 01/2013
3	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2014 - 01/2012
3	Wolman Disease (Wolman's Disease) 07/2014 - 07/2002
2	Brain Diseases (Brain Disorder) 01/2021 - 01/2016
2	Atherosclerotic Plaque (Atheroma) 01/2018 - 01/2004
2	Anemia 01/2017 - 02/2004
2	Thrombocytopenia (Thrombopenia) 01/2017 - 02/2004
2	Gliosis 01/2016 - 02/2015
2	Lymphadenopathy 02/2015 - 02/2007
2	Metachromatic Leukodystrophy due to Saposin B Deficiency 07/2013 - 06/2013
2	Tremor (Tremors) 06/2013 - 06/2008
2	Mucopolysaccharidoses 01/2012 - 12/2007
2	Rare Diseases (Rare Disease) 01/2012 - 03/2008
2	Synucleinopathies 07/2011 - 07/2011
2	Central Nervous System Diseases (CNS Diseases) 07/2010 - 06/2008
2	Metabolic Bone Diseases (Osteopenia) 08/2005 - 09/2004
2	Mucopolysaccharidosis I (Hurler Syndrome) 07/2003 - 01/2003
1	Neuroinflammatory Diseases 10/2019
1	Inborn Genetic Diseases (Disease, Hereditary) 09/2016
1	Ataxia (Dyssynergia) 01/2016
1	Paresis (Hemiparesis) 01/2016
1	Hearing Loss (Hearing Impairment) 02/2015
1	Lung Diseases (Lung Disease) 02/2015
1	Laurence-Moon Syndrome (Syndrome, Laurence-Moon) 02/2015
1	Proteostasis Deficiencies 08/2014
1	Glioma (Gliomas) 01/2014

Drug/Important Bio-Agent (IBA)

31	Glucosylceramidase (Glucocerebrosidase)IBA 01/2018 - 01/2003
21	AcidsIBA 05/2020 - 02/2006
20	GlucosidasesIBA 05/2020 - 07/2010
18	Glucosylceramides (Glucocerebrosides)IBA 01/2018 - 02/2004
14	EnzymesIBA 05/2020 - 01/2003
10	SaposinsIBA 05/2020 - 10/2005
8	sphingosyl beta-glucosideIBA 12/2015 - 03/2010
7	LipidsIBA 01/2018 - 07/2002
5	imiglucerase FDA Link 01/2017 - 02/2009
5	Sterol Esterase (Hormone-Sensitive Lipase)IBA 07/2014 - 01/2004
4	CytokinesIBA 01/2017 - 07/2012
4	SynucleinsIBA 08/2014 - 06/2011
3	Messenger RNA (mRNA)IBA 10/2019 - 01/2013
3	GlycosphingolipidsIBA 12/2017 - 07/2010
3	UbiquitinIBA 02/2015 - 07/2011
2	ProgranulinsIBA 02/2018 - 09/2016
2	Complement System Proteins (Complement)IBA 01/2018 - 01/2017
2	Lysergic Acid Diethylamide (LSD)IBA 01/2018 - 08/2014
2	GangliosidesIBA 12/2017 - 07/2010
2	Immunoglobulin G (IgG)IBA 01/2017 - 05/2010
2	ceramide glucosyltransferaseIBA 01/2016 - 07/2007
2	TOR Serine-Threonine KinasesIBA 12/2015 - 01/2014
2	CeramidesIBA 01/2015 - 05/2009
2	Proteins (Proteins, Gene)FDA Link 08/2014 - 10/2006
2	ChemokinesIBA 02/2014 - 01/2013
2	isofagomineIBA 02/2012 - 04/2011
2	HydrolasesIBA 07/2010 - 07/2010
2	conduritol epoxideIBA 06/2008 - 02/2006
1	Glial Fibrillary Acidic ProteinIBA 10/2019
1	Biomarkers (Surrogate Marker)IBA 02/2018
1	Chitinase-3-Like Protein 1IBA 02/2018
1	CholesterolIBA 01/2018
1	Lipoproteins (Lipoprotein)IBA 01/2018
1	InflammasomesIBA 01/2018
1	CDw17 antigen (lactosylceramide)IBA 12/2017
1	Hemoglobins (Hemoglobin)IBA 01/2017
1	AutoantibodiesIBA 01/2017
1	Anaphylatoxin C5a ReceptorIBA 01/2017
1	Biological ProductsIBA 01/2017
1	Complement C5a (Complement 5a)IBA 01/2017
1	Dantrolene (Dantrium)FDA LinkGeneric 12/2016
1	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 12/2016
1	Adenosine Triphosphate (ATP)IBA 12/2016
1	venglustatIBA 01/2016
1	Epoxy Compounds (Epoxides)IBA 01/2016
1	GlycolipidsIBA 01/2016
1	MicroRNAs (MicroRNA)IBA 12/2015
1	Eukaryotic Initiation Factor-2 (EIF 2)IBA 12/2015
1	neurotoxic esteraseIBA 02/2015
1	Interleukin-6 (Interleukin 6)IBA 01/2015
1	p38 Mitogen-Activated Protein KinasesIBA 01/2015
1	Phosphotransferases (Kinase)IBA 01/2015
1	Amyloid (Amyloid Fibrils)IBA 08/2014
1	Chemotactic FactorsIBA 02/2014
1	Antineoplastic Agents (Antineoplastics)IBA 01/2014
1	AICA ribonucleotide (ZMP)IBA 01/2014
1	Metformin (Glucophage)FDA LinkGeneric 01/2014
1	Galactosylceramides (Galactocerebrosides)IBA 06/2013
1	AT 61IBA 06/2013
1	Sulfoglycosphingolipids (Sulfatides)IBA 06/2013

Therapy/Procedure

17	Therapeutics 01/2021 - 11/2003
17	Enzyme Therapy 01/2017 - 01/2003
8	Enzyme Replacement Therapy 05/2020 - 09/2004
2	Injections 05/2010 - 09/2004
1	Intravenous Infusions 10/2019
1	Transplantation 10/2019